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Buy Mildronate online first developed in 1989 by the former Soviet Union for the first time the company Grindeks on sale now at La Via, Russia, Ukraine, Belarus, Azerbaijan, Armenia, Moldova, Lithuania and other 15 countries listed, the drug is a structural analogue of carnitine, carnitine can compete with the top three amino γ- butyrolactone salt hydroxylase, reduce cell free carnitine and acetyl carnitine concentrations of long-chain, thereby inhibiting the oxidation of fatty acids carnitine dependent.
Currently, commonly used in clinical treatment of myocardial ischemia traditional drugs following categories: nitrates, β-blockers, calcium channel blockers and lipid-lowering and so on. Their main mechanism of action is relaxation of vascular smooth muscle, vascular smooth muscle and coronary dilatation, reducing myocardial oxygen consumption and lower blood lipids. Due to coronary heart disease mortality is still high. Metabolic disorders myocardial ischemia reperfusion has been highly concerned about the medical workers in recent years, to improve myocardial metabolism of drugs against myocardial ischemia-reperfusion injury in terms of attention of many scholars. Meldonium site of action in the mitochondria, the cellular level improve myocardial energy metabolism. Given the significant difference between such drugs and other anti-ischemic drugs, also known as cellular anti-ischemic drugs.
Pharmacological effects
1 Buy Mildronate online can improve energy metabolism of myocardial cells to provide energy to the tissue through anaerobic glycolysis, improve myocardial ischemia, hypoxia symptoms, with other drugs (such as vasodilators, diuretics, etc.) combined for the treatment of ischemic heart disease.
2 Mildronate promotes redistribution of blood in the heart and brain ischemic area for a variety of acute and chronic treatment of cerebral circulation disorders.
3 the drug by improving fat metabolism, can improve people's ability to work, relieve mental and physical over-stress syndrome, athletes taking the drug may improve athletic performance during training and competition.
4 To eliminate chronic alcoholism during abstinence syndrome patients with seizure of their nervous system and damage, in addition to the drug may also improve due to nutritional disorders caused by retinal vascular lesions.
5 Membrane protective effect: when the effort causing ischemic myocardial cell stress response, the inner mitochondrial fatty acid decomposition increased cell fatty acid metabolite accumulation, means the destruction of the cell membrane, increase intracellular Ca ++.
6 The energy optimization of the role:
Mildronate help us to lessen the capacity of accumulation of long chain acyl carnitine, carnitine-dependent fatty acid oxidation can be suppressed, so that the fatty acid oxidation to glucose oxidation more favorable anoxic myocardial energy metabolism, namely promote anaerobic glycolytic pathway of oxidation, so this product has anti-anoxia utility and cardioprotective activity.
7 Effects on energy metabolism enzymes:
Buy Mildronate online isoproterenol-induced strengthening can prevent blood lactate dehydrogenase (cardiac-specific isozyme) liver different life, to prevent the increase in the activity of creatine phosphokinase.
8 On the excretion of carnitine: Another study shows that Mildronate competitive inhibition in vivo in addition to butyric acid betaine-hydroxylase, blocking the biosynthesis of carnitine, but also the competitive impact of carnitine reabsorption in the kidney.
9 For the protection of the ischemic heart: myocardial ischemic area, left anterior descending artery occlusion not only reduces the tissue levels of ATP, ADP and creatine phosphate, also increased tissue levels of AMP and lactate, reduce energy charge potential the value of. The results in Table Mingmi flexor hydrazine inhibit β- oxidation of fatty acids and thus the ischemic myocardium energy metabolism is very beneficial.
This information is by Chemicalbook Xiaonan editor (2015-08-20).
Indications
Cardiovascular disease - unstable angina, congestive heart failure, cardiomyopathy, functional cardiovascular system failure; acute and chronic ischemic attack; reduced ability to work under high load physical and psychological mood; cerebrovascular disease, brain injury and brain after recovering from inflammation. Alcohol withdrawal symptoms.
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